Refractory chronic cough
Conditions
Interventions
control group:Inject 0.1mL normal saline into the unilateral arytenoid muscle by OT syringe
experimental group:Inject BTX-A 1.25U into the unilateral arytenoid muscle by OT syringe
Sponsors
Tongji Hospital Affiliated to Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18 - 60 years are not limited to men and women; 2. Patients with cough as the main symptom, cough time more than 8 weeks, and no obvious abnormality on chest X-ray or CT; 3. Patients with chronic cough whose cause is still unclear after comprehensive examination according to the chronic cough diagnosis procedure of Chinese cough diagnosis and treatment guidelines (2015) or whose treatment for known cause is still unresponsive; 4. Patients with cough visual analogue score (VAS) >= 50 mm; 5. Patients willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with asthma, urticaria or allergic reaction induced by BTX-A; 2. Patients with severe heart failure and coronary artery bypass grafting (CABG) in perioperative period; 3. Patients with liver and kidney dysfunction; 4. Pregnant women and lactating women; 5. Patients with myasthenia gravis and multiple sclerosis; 6. Patients with ptosis; 7. Patients with dysphagia and cough caused by any etiology; 8. Smoking patients or patients who have quit smoking for less than 1 year; 9. Patients with upper respiratory tract infection within 4 weeks; 10. Patients who need ACEI drugs for a long time; 11. Patients with moderate or more obstructive or restrictive or mixed pulmonary ventilation dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough symptom score;Leicester Cough Questionnaire score;Visual Analogue Score; | — |
Countries
China
Contacts
Public ContactXu Xianghuai
Tongji Hospital Affiliated to Tongji University
Outcome results
None listed