Non-cystic fibrosis bronchiectasis
Conditions
Interventions
Control group:Placebo
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 87 Years
Inclusion criteria
Inclusion criteria: 1. Obtain written informed consent; 2. Aged >= 18 years; 3. High resolution computed tomography (HRCT) diagnosis of non cystic fibrosis bronchiectasis; 4. FEV1 >= 30% predicted value; 5. Basic SGRQ score >= 30 points; 6. At least 2 times of aggravation of lung requiring oral antibiotics or at least 1 time of aggravation of lung requiring intravenous antibiotics in the past 12 months; 7. Stable period (no aggravation) >= 30 days.
Exclusion criteria
Exclusion criteria: 1. Cystic fibrosis bronchiectasis; 2. Previous use of NAC for more than 2 weeks; 3. Rescue antibiotic treatment within 4 weeks before screening (except for chronic basic anti infective treatment); 4. Terminal stage or waiting for organ transplantation; 5. Recorded chronic asthma, allergic bronchopulmonary aspergillosis (ABPA), active or actively treated pulmonary nontuberculous branching rod NTM infection; 6. Myocardial infarction, cerebrovascular accident, major operation and other events in the past 3 months; 7. Active tuberculosis or malignant diseases; 8. Pregnant women in pregnancy, lactation or planned next year, or patients who may be pregnant but refuse to take contraceptive measures at least 1 month before enrollment and the whole trial period; 9. Patients with acetylcysteine allergy; 10. Other circumstances which researchers think it's not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SGRQ change from baseline;Annual exacerbation rates; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to first exacerbation;Annual hospitalization rates;SGRQ sub-score change from baseline; | — |
Countries
China
Contacts
Public ContactFuqiang Wen
West China Hospital, Sichuan University
Outcome results
None listed