Endometriosis
Conditions
Interventions
Sponsors
Department of Gynecology and Obstetrics Hospital Affiliated to Zhejiang University Medical College
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Female, over 18 years old, who agree to use GnRHa and mifepristone for treatment and sign the informed consent; 2. Patients with endometriosis confirmed by outpatient or ward auxiliary examination such as B-ultrasound and / or magnetic resonance imaging (MRI) should not be operated temporarily, or diagnosed as endometriosis by pathology after operation; 3. Dysmenorrhea with or without menorrhagia; 4. Patients who request to keep the uterus or give birth; 5. Patients who did not receive other hormone drugs for endometriosis within 3 months before the drug treatment; 6. Patients with normal or non clinically significant cervical cytology results (results within 6 months before screening period).
Exclusion criteria
Exclusion criteria: 1. Patients with pelvic pain, vaginal bleeding and other symptoms caused by unknown or non endometriosis; 2. Patients diagnosed as endometrial polyp, submucous myoma and other benign lesions or suspicious malignant tumors by B-ultrasound; 3. Patients receiving other hormone drugs for endometriosis; 4. Patients who are using other drugs that interact with the study drug and cannot stop the drug; 5. Patients with serious heart, liver and kidney diseases and adrenal cortex dysfunction; patients with drug allergy or allergic constitution; 6. Patients who have participated in other clinical trials within 3 months and who other personnel think are not suitable to participate in the trial. 7. Patients with fertility requirements have poor ovarian reserve function: basic endocrine FSH > 10iu / L, the number of follicles in bilateral sinuses is less than 3-5, AMH < 1.1ng/ml.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain score;change of menstrual volume;the level of CA125;lesion size;liver function;blood lipid level;reproductive hormone level;endometrial thickness; | — |
Countries
China
Contacts
Public ContactXinmei Zhang
Department of Gynecology and Obstetrics Hospital affiliated to Zhejiang University Medical College
Outcome results
None listed