knee arthroplasty,central sensitization
Conditions
Interventions
A:Central sensitization patients(Medicine for central sensitization)
B:Central sensitization patients(placebo)
C:Normal patients (No-treatment Control)
Sponsors
Department of Joint Surgery, Ningbo Sixth Hospital
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients with severe knee osteoarthritis waiting for replacement surgery,; 2. Aged 50 years or older; 3. Objects of culture above primary school; 4. Participants who voluntarily participate in the study and can provide written informed consent.
Exclusion criteria
Exclusion criteria: 1. People with mental disorder, personality disorder and substance abuse / dependence; 2. Subjects who refused to participate in the study due to stress events in the past week; 3. Subjects who did not have knee replacement surgery, patients who use non surface replacement joint prosthesis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Knee Osteoarthritis Outcome Score, KOOS;Visual Analogue Scale/Score, VAS;Central Sensitization Inventory, CSI; | — |
Secondary
| Measure | Time frame |
|---|---|
| knee function (HHS, ROM, WOMAC);complication; | — |
Countries
China
Contacts
Public ContactLing Jing
Ningbo Sixth Hospital
Outcome results
None listed