Adenomyosis
Conditions
Interventions
1:dinogest
2:mifepristone
3:GnRHa, dinogest
4:GnRHa, mifepristone
Sponsors
Women's Hospital, School of Medicine, Zhejiang University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Female, over 18 years old, the patient agreed to use GnRHa and dinogest mifepristone for treatment and signed the informed consent form; 2. outpatient or ward auxiliary examination such as vaginal B-ultrasound and / or magnetic resonance imaging (MRI) confirmed as adenomyosis requiring temporary surgery, or pathological diagnosis after surgery as adenomyosis; 3. dysmenorrhea with or without menorrhagia; 4. required to keep the uterus Or fertility; 5. within 3 months before drug treatment, none of them received other hormone drugs for adenomyosis; 6. normal or clinically insignificant cervical cytology results (results within 6 months before screening period).
Exclusion criteria
Exclusion criteria: 1. Symptoms such as pelvic pain and vaginal bleeding caused by unknown or non adenomyosis; 2. B Ultrasound diagnosis of endometrial polyps, submucous myomas and other benign lesions or suspicious malignant tumors; 3. receiving other hormone drugs for adenomyosis; 4. using other drugs that interact with the drugs in this study and can not be stopped; 5. patients with serious heart, liver, kidney diseases and adrenal cortex dysfunction; drug allergy or allergic constitution; 6. They have participated in other clinical trials within 3 months; and factors that other personnel think are not suitable to participate in the trial; 7. patients with fertility requirements have poor ovarian reserve function: basic endocrine FSH > 10 IU/L, the sum of follicles in bilateral sinuses is less than 3-5, AMH < 1.1ng/ml.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain score;change of menstrual volume;the level of CA125;the volume of the uterus;liver function;blood lipid level;reproductive hormone level;endometrial thickness; | — |
Countries
China
Contacts
Public ContactXinmei Zhang
Women's Hospital, School of Medicine, Zhejiang University
Outcome results
None listed