Effects of oxycodone combined with low dose dexamethasone on hemodynamics, postoperative analgesia and adverse reactions in patients undergoing laparoscopic cholecystectomy under general anesthesia

Effects of oxycodone combined with low dose dexamethasone on hemodynamics, postoperativeanalgesia and adverse reactions in patients undergoing laparoscopic cholecystectomy under general anesthesia

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000031654

Enrollment

Unknown

Registered

2020-04-06

Start date

2020-05-01

Completion date

Unknown

Last updated

2020-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative analgesia

Interventions

Three groups:Control vs oxycodone vs oxycodone+dexamethasone

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Adult patients (18-65 years old) with ASA I ~ II who underwent selective laparoscopic cholecystectomy in Shengjing Hospital Affiliated to China Medical University were selected.

Exclusion criteria

Exclusion criteria: 1. Patients who are allergic to oxycodone or fentanyl; 2. Long term use of oxycodone or fentanyl drugs in patients; 3. Patients taking other analgesics; 4. Pregnant and lactating patients; 5. Patients who are converted to open surgery or additional surgery; 6. Patients with liver, kidney, heart or respiratory diseases; 7. Patients with contraindications to dexamethasone and oxycodone; 8. Patients with complex symptoms of cholecystitis or gallstone; 9. People who smoke a lot for a long time; 10. Patients with cognitive impairment; 11. Underweight and obese patients; 12. Patients with poor hypertension control.

Design outcomes

Primary

Measure	Time frame
VAS grade of postoperative analgesia;	—

Secondary

Measure	Time frame
???????? Postoperative nausea and vomiting score;	—

Countries

China

Contacts

Public ContactHongzhi Chen

Shengjing Hospital of China Medical University

chenhz@sj-hospital.org+86 18940259975

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026