Chronic thromoboembolic pulmonary hypertension
Conditions
Sponsors
Shanghai Pulmonary Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Chronic thromboembolic pulmonary hypertension (CTEPH) patients
Exclusion criteria
Exclusion criteria: 1. Patients with absolute contraindications: (1) Acute myocardial infarction (within 2 days); (2) Uncontrolled unstable angina; (3) Uncontrolled arrhythmia leads to hemodynamic instability; (4) Acute endocarditis; (5) Symptomatic severe coarctation of the aorta; (6) Decompensated heart failure; (7) Acute pulmonary embolism, pulmonary infarction or deep vein thrombosis; (8) Acute myocarditis or pericarditis; (9) Acute aortic dissection; (10) Disabled people have potential safety hazards or can not fully complete the exercise test. 2. Patients with relative contraindications: (1) Stenosis of the left main coronary artery was known; (2) Moderate to severe aortic stenosis was associated with uncertain symptoms; (3) Uncontrolled ventricular tachycardia; (4) Acquired high or complete atrioventricular block; (5) Severe hypertrophic obstructive cardiomyopathy (high pressure difference in resting outflow tract); (6) Recent stroke or transient ischemic attack; (7) Those who are difficult to cooperate with; (8) Resting blood pressure > 200 / 110mmhg; (9) Uncorrected clinical problems such as severe anemia, electrolyte disorders, and hyperthyroidism. 3. WHO group 2 pH /WHO group 3 PH /WHO group 5 pH
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| peak VO2/kg;Proteomics, transcriptome; | — |
Secondary
| Measure | Time frame |
|---|---|
| 6MWT;WHO FC;Cardiopulmonary exercise testing;Echocardiography;Stress echocardiography;Capography;Cardiac MRI;NT-proBNP;biochemistry; | — |
Countries
China
Contacts
Public ContactJiang Rong
Shanghai Pulmonary Hospital
Outcome results
None listed