Acute lymphoblastic leukemia
Conditions
Interventions
preventive intervention:Zoledronic acid combined with calcium , vitamin D
therapeutic intervention:Zoledronic acid combined with calcium , vitamin D
Sponsors
Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Male or female patients aged 18-65 years; 2. Patients with primary acute lymphoblastic leukemia; 3. Patients without serious heart disease or coronary heart disease history; 4. Patients with liver and kidney function suitable for chemotherapy: SGOT and SGPT should not exceed 2 times of the upper limit of normal; total bilirubin in serum should not exceed 1.5 times of the upper limit of normal; 5. Patients with normal amylase and no previous history of pancreatitis; 6. Patients willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with uncontrollable diabetes; 2. HIV and syphilis infected patients; 3. Pregnant or lactating women; 4. Patients who have received organ transplantation in the past; 5. Patients with serious neurological or psychiatric history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone metabolism (bone density, serum bone metabolism indicators); | — |
Secondary
| Measure | Time frame |
|---|---|
| CR;overall survival, OS;minimal residual disease, MRD;safety; | — |
Countries
China
Contacts
Public ContactJin Wang
Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of medicine
Outcome results
None listed