cognitive dysfunction
Conditions
Interventions
propofol group:propofol
Sponsors
Air Force Medical University of PLA (the Fourth Military Medical University)
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Aged 65-80 years; 2) Patients with laparoscopic / open gastrointestinal and hepatobiliary operations under general anesthesia and the operation time <= 4H; 3) ASA grades I to III; 4) BMI is 18.5-29.9 kg / m2 [BMI = weight (kg) / height (M2)] (2013 US "guidelines for the management of adult overweight and obesity); 5) In line with the ethics, the patient voluntarily tested and signed the informed consent.
Exclusion criteria
Exclusion criteria: 1) Any cerebrovascular accident occurred within 3 months, such as stroke, TIA, etc.; 2) Severe liver and kidney dysfunction (severe liver dysfunction: alt, conjugated bilirubin, AST, ALP, one of total bilirubin > 2 times of the upper limit of normal value; severe renal dysfunction: Cr clearance = 180/110 mm Hg (WHO-ISH hypertension guideline grade 3 hypertension); 6) Identify/suspect abuse or long-term use of narcotic sedatives and analgesics; 7) Take hormone or other immunosuppressant for more than 10 days within half a year or have a history of adrenal cortex inhibition or immune system disease; 8) Hypothyroidism; 9) With a history of asthma; 10) Reoperation within 3 months; 11) There are contraindications or allergies to test drugs and other narcotic drugs; 12) Patients who participated in other studies within 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BP;HR;cognitive function;SpO2; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function;Kidney function;BIS;Cortisol, aldosterone and ACTH;VAS; | — |
Countries
China
Contacts
Public ContactHongguang Bao
Nanjing First Hospital
Outcome results
None listed