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The effects and mechanisms of interaction between gene polymorphism and factty acid on premature coronary heart disease

The effects and mechanisms of interaction between gene polymorphism and factty acid on premature coronary heart disease

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000031498
Enrollment
Unknown
Registered
2020-04-02
Start date
2020-05-01
Completion date
Unknown
Last updated
2020-04-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

premature coronary heart disease

Interventions

premature coronary heart disease group:N/A

Sponsors

Shunde Hospital, Southern Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged >= 18 years, premature coronary heart disease is defined as male <= 55 years old, female <= 65 years old and clearly diagnosed with coronary heart disease. 2. The selected patients in the case group strictly followed the diagnostic criteria of coronary heart disease established by the American college of cardiology and the American heart association in 2000. All patients had paroxysmal or persistent precardiac pain, and were diagnosed as acute myocardial infarction by coronary angiography or coronary artery CTA, indicating more than 50% coronary artery stenosis, or by electrocardiogram and myocardial enzyme examination. 3. Patients in the control group were inpatients and outpatients without coronary atery disease confirmed by coronary angiography or coronary artery CTA.

Exclusion criteria

Exclusion criteria: 1. Patients who are suffering from other diseases that affect lipid and fatty acid metabolism, such as thyroid disease, nephrotic syndrome, etc.; 2. Patients who have hematological system diseases, severe liver and kidney dysfunction, acute and chronic infections, autoimmune diseases, and take on medications that affect fatty acid metabolism; 3. Patients who have heart diseases such as dilated cardiomyopathy and rheumatic heart disease; 4. Patients who take vitamin or fish oil supplements for more than 1 month.

Design outcomes

Primary

MeasureTime frame
rehospitalization rate for myocardial infarction;heart failure;all cause mortality;

Countries

China

Contacts

Public ContactYuli Huang

Shunde Hospital, Southern Medical University

hyuli821@163.com+86 15099882157

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026