Rosacea
Conditions
Interventions
experimental group:Paroxetine
control group:placebo
Sponsors
Xiangya Hospital Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Definition of intractable rosacea: after 12 weeks of oral administration of conventional drugs such as doxycycline, with or without other treatments (topical drugs /IPL, etc.), patients with treatment resistance (erythema not reduced by 1 grade or erythema greater than or equal to 3 degrees), or patients with frequent recurrence during 12 weeks of treatment. And signed the informed consent voluntarily.
Exclusion criteria
Exclusion criteria: Subjects who meet one of the following conditions will not be included in the study: (1) Age 65 years old. (2) Pregnant and breastfeeding women and with recent pregnancy plans. (3) With nasal hyperplasia hypertrophy rosacea patients. (4) Patients with moderate or severe liver, kidney, lung or blood and other systemic diseases. (5) Suspected gastric acid deficiency, acute or chronic gastrointestinal ulcer or duodenal surgery (cannot absorb drugs). (6) History of mental illness. (7) Paroxetine allergy. (8) Patients with oral amine oxidase inhibitors (such as phenylethylhydrazine, seligilan, etc.). (9) Topical treatment was given within 2 weeks, systemic treatment with common drugs within 4 weeks or isotretinoic acid within 6 months. (10) Combined with other facial skin diseases (such as seborrheic dermatitis, eczema, etc.) or the facial manifestations of other diseases (such as dermatomyositis, systemic lupus erythematosus). (11) Patients who are not expected to follow up. (12) Participants in any clinical trial within one month. (13) Other ineligible conditions were considered by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Assessment of clinical severity of rosacea;Assessment of clinical severity of rosacea; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life scale for patients with rosacea;Anxiety and depression rating scale;A clinical photograph of the face of a patient with rosacea;A VISIA photograph of the face of a patient with rosacea; | — |
Countries
China
Contacts
Public ContactHongfu Xie
Department of Dermatology, Xiangya Hospital, Central South University
Outcome results
None listed