Cardiovascular effects of prophylactic intravenous methoxamine in patients undergoing painless gastrointestinal endoscopy: a randomized controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000031459

Enrollment

Unknown

Registered

2020-04-01

Start date

2020-04-15

Completion date

Unknown

Last updated

2020-04-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamics

Interventions

Methoxamine Group:Methoxamine 1~2 mg was administered immediately after anesthesia induction

Control group:Normal saline 1~2 ml was administered immediately after anesthesia induction

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patients undergo painless gastrointestinal endoscopy; 2. 18~75 years old; 3. ASA I~III.

Exclusion criteria

Exclusion criteria: 1. Basic heart rate = 180 mmHg or diastolic blood pressure) >= 110 mmHg; 3. Patients with malignant arrhythmia and cardiac function grade >= 3 of New York Heart Association (NYHA); 4. Patients with difficult airway and high risk of regurgitation and aspiration; 5. Patients with chronic renal failure; 6. Patients who are allergic to methoxyphen.

Design outcomes

Primary

Measure	Time frame
Blood Pressure;	—

Secondary

Measure	Time frame
Procedure time;Recovery time;Doses of anesthetics;Doses of vasoactive medications;Bradycardia;Hypoxia;Nausea;Vomitting;	—

Countries

China

Contacts

Public ContactHaorui Sun

Beijing Friendship Hospital Affiliated to Capital Medical University

sunhaorui1989@163.com+86 10-63138780

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026