Acute kidney injury
Conditions
Interventions
Gold Standard:Clinical outcome: KDIGO recommends AKI diagnostic criteria: Scr increases more than 26.5 µmol / l (0.3 mg / dl) within 48 hours
Scr increases 1.5 times above baseline-confirmed or speculated to occur within 7 days
urine output per hour is less than 0.5 ml / kg for 6 hours the above. (Because
Index test:urine exosomes
Sponsors
The First People‘s Hospital of Foshan
Eligibility
Sex/Gender
All
Age
15 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients will undergo cardiac surgery under elective extracorporeal circulation; 2. Age 15-80 years old; 3. Voluntarily participate in the experiment and sign the consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of chronic kidney disease before surgery and urinalysis and clinical manifestations before and / or 3 days after surgery suggest that a urinary tract infection exists; 2. Nephrotoxic drugs have been used before or during the study; 3. Those with unstable vital signs before surgery; 4. Cardiac arrest during surgery or death within 48 hours after surgery; 5. With other serious diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urine exosomes;SEN, SPE, ACC, AUC of ROC; | — |
Countries
China
Contacts
Public ContactJun Zhou
The First People‘s Hospital of Foshan
Outcome results
None listed