epilepsy
Conditions
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 9 to 55 years; 2. To avoid structural lesions that induced epilepsy, choose patients with brain MRI-Negative manifestations; 3. The duration of epilepsy over 1 year; 4. Right to left shunt of PFO confirmed by transthoracic echocardiography
Exclusion criteria
Exclusion criteria: 1. The epilepsy patients with definite CNS etiologic causes such as hippocampal sclerosis, cerebral trauma, tumor, cerebrovascular diseases, degenerative diseases, immunologic disorders, demyelinating disorders, cerebral infection, and so on. Especially, given the common cause of epilepsy in China is cerebral infarction, the conditions that any probable lacunar infarct in MRI or suspicious history of transient ischemic attack(TIA); 2. Family history of epilepsy; 3. With medical history of heart diseases and central nervous system (CNS) organic diseases; 4. Left to right shunt of PFO or other cardiac diseases (such as atrial septal defect) found by TTE.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proteomics;fMRI;genomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of seizures; | — |
Countries
China
Contacts
Public ContactChen Lei
West China Hospital, Sichuan University
Outcome results
None listed