Depressive disorder
Conditions
Interventions
drug group:N/A
Active control group:N/A
Sponsors
Peking University Sixth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) aged 18-75, male or female, outpatient or inpatient; (2) patients diagnosed as having a single or repeated depressive episode, depression with sleep disturbance, or psychotic depression according to the tenth edition of the international classification of diseases (icd-10); (3) patients who met the second inclusion criteria and received agomelatine for the first time; (4) patients who met the second inclusion criteria and used other antidepressants (SSRI, SNRI, NaSSA) for the first time; (5) the research objects included in the early stage formed "knowledge" through the later stage of big data modeling, mining, evaluation and optimization, and then extracted the patients who used agomelatine and liver protection drugs at the same time; (6) variables such as the unique identification number, gender, age, medication name and time of the study population were extracted from the database; (7) in this study, patient information was anonymized; (8) pass the ethical review by the ethics committee.
Exclusion criteria
Exclusion criteria: Patients who were not considered suitable to participate in the study in conjunction with other investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MAMD-17?CGI-S?CGI-I;AST?ALT; | — |
Secondary
| Measure | Time frame |
|---|---|
| electrocardiography;Routine blood examination (white blood cells, red blood cells, neutrophils, lymphocytes);Coagulation routine (partial thrombin time, prothrombin time, international standardized ratio, thrombin time);PSQI, ASEX; | — |
Countries
China
Contacts
Public ContactSi Tianmei
Peking University Sixth Hospital
Outcome results
None listed