Liver failure
Conditions
Interventions
Group A:double plasma molecular adsorption system
Group B:Double plasma molecular adsorption system combined with Plasma exchange
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years. 2. Patients with liver failure who received double plasma molecular adsorption system ( DPMAS ) combined with plasma exchange ( PE ) for therapy were enrolled. The diagnosis of liver failure was mainly based on the Guidelines for the diagnosis and treatment of liver failure in 2018. 3. Patients with informed consent.
Exclusion criteria
Exclusion criteria: 1. The existence of plasma replacement contraindications: serious allergies to plasma, human serum albumin, heparin and others; the existence of mental disorders; Systemic circulatory failure that is difficult to treat with drug; With irreversible serious central nervous system diseases such as cerebral hernia formation. 2. Patients with renal failure caused by renal basic diseases or Patients who had received long-term anticoagulant therapy. 3. On the verge of death or Patients with terminal stage of malignant tumor. 4. Without informed consent, and other circumstances may bring significant bias.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total bilirubin;Prothrombin activity; | — |
Secondary
| Measure | Time frame |
|---|---|
| albumin;Alanine transaminase;Time of transfer from ICU;Blood ammonia; | — |
Countries
China
Contacts
Public ContactYing Ye
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed