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Efficacy and safety of prolyl hydroxylase inhibitors on erythropoietin hypo-responsiveness in hemodialysis patients with renal anaemia a prospective cohort study

Efficacy and safety of prolyl hydroxylase inhibitors on erythropoietin hypo-responsiveness in hemodialysis patients with renal anaemia a prospective cohort study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000031351
Enrollment
Unknown
Registered
2020-03-28
Start date
2020-05-01
Completion date
Unknown
Last updated
2020-04-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Renal anemia

Interventions

prolyl hydroxylase inhibitors group:prolyl hydroxylase inhibitors

Sponsors

Ya'an People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. From January 2018 to January 2021, patients with renal anemia during maintenance hemodialysis in hemodialysis center of renal Department of Ya'an people's Hospital; 2. Patients with dialysis 3 times a week, single kt / V > 1.2, dialysis age >= 12 weeks; 3. Patients who were diagnosed as renal anemia (hemoglobin = 300iu / (kg? W). 5. The study is designed for 24 weeks. A single center observational clinical study is conducted.

Exclusion criteria

Exclusion criteria: 1. Patients younger than 18 years old; 2. Patients with any other anemia caused by diseases other than CKD, such as thalassemia, sickle cell anemia, pure red cell aplasia, tumor related anemia, chemotherapy-related anemia, myelodysplastic syndrome, etc; 3. Pregnant and lactating women; 4. Patients who are allergic to treatment drugs; 5. Patients with serious diseases judged by doctors; 6. Patients with existing malignant tumors.

Design outcomes

Primary

MeasureTime frame
hemoglobin;

Secondary

MeasureTime frame
hepcidin;superoxide dismutase;C-reactive protein;triglyceride;Cholesterol;Serum uric acid;Transferrin saturation;Ferritin;

Countries

China

Contacts

Public ContactHen Xue

Ya'an People's Hospital

445960797@qq.com+86 13551595297

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026