recurrent miscarriages and failed repeated implantation
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: (1) Patients aged 23-43 years, with the number of miscarriages >= 2 times, or with the transfer cycle of 1-2 high-quality embryos for more than 3 consecutive times and unable to obtain pregnancy; (2) Abnormal immune function; (3) Patients with abnormal glucose and lipid metabolism; (4) Blood lead concentration > 20ug/l.
Exclusion criteria
Exclusion criteria: (1) Patients with chromosomal abnormalities and other genetic problems; (2) Abnormal anatomical structure of the uterus, such as mediastinal uterus, cervical dysfunction; (3) Patients with thyroid diseases, high prolactinemia and other endocrine abnormalities; (4) Patients with genital tract infection; (5) The influence of bad living habits and environmental factors, such as smoking, drinking, excessive exposure to harmful chemicals, etc..
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| D - lactic acid;diamine oxidase;endotoxin;5-hydroxytryptamine;blood lead;blood routine examination;hepatic and renal function;purine trione;cholesterol;triglyceride;high-density lipoprotein;low density lipoprotein;insulin;Glucose tolerance;glycosylated hemoglobin;fructosamine;Inflammatory body mass index;interleukin-6;tumor necrosis factor-alpha;intestinal flora; | — |
Countries
China
Contacts
Shenzhen Maternity and Child Healthcare Hospital