Bronchial Asthma
Conditions
Sponsors
Huashan Hospital affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: For bronchial asthma: 1. Age ranged from 30-60 years old without gender limitation; 2. Patients diagnosed with bronchial asthma according to the "2016 guidelines for the prevention and treatment of bronchial asthma of the Chinese respiratory society" and the "2019GINA". 3. With no history of respiratory diseases except bronchial asthma; 4. With no respiratory infection within 4 weeks, no acute exacerbation of asthma within 3 months; 5. With no smoking history or quiting smoking for more than 12 months; 6. Patients who voluntarily participate in the study and sign the informed consent. For health control: 1. Age ranged from 30-60 years old without gender limitation; 2. Normal physical examination, no abnormal disease history, no abnormal symptoms or signs; 3. All test results should be normal, or the abnormalities have no clinical significance (including laboratory and imaging tests); 4. Patients with no history of upper and lower respiratory tract infection in the past 4 weeks and without glucocorticoid treatment; 5. Blood routine examination, lung function and allergen detection results should be normal; 6. With no smoking history or quiting smoking for more than 12 months; 7. Patients who voluntarily participate in the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: For bronchial asthma: 1. Patients with severe duration or acute attack asthma who require oral treatment with glucocorticoids; 2. Patients who received antibiotics within 4 weeks; 3. Patients with pulmonary diseases such as COPD, lung tumor, interstitial lung disease, and active pulmonary tuberculosis; 4. Patients with severe impairment of heart, liver and kidney function (grade 3-4, ALT and/or AST exceeding 1.5 times the normal upper limit, Cr exceeding the normal upper limit); 5. Patients with rheumatic immune diseases and adrenocortical dysfunction who need to use hormones and immunosuppressants; 6. Patients with chronic diseases such as diabetes, cardiovascular and cerebrovascular diseases, and malignant tumors; 7. Women who are pregnant or during suckling period within 1 year; 8. Those who the researchers think are not suitable to participate in the study; 9. Participating in other clinical researchers at the same time. For health control: 1. Patients who received antibiotics within 4 weeks; 2. Women who are pregnant or during suckling period within 1 year; 3. Those who the researchers think are not suitable to participate in the study; 4. Participating in other clinical researchers at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| long function;whole transcriptome resequencing;Peripheral blood eosinophil count;Blood immunoglobulin E; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peripheral blood inflammatory cytokines;Oxidase activity in peripheral blood; | — |
Countries
China
Contacts
Public ContactDong Jingcheng, Wei Ying
Huashan Hospital, Fudan University
Outcome results
None listed