AIDS-associated toxoplasma encephalitis
Conditions
Interventions
the early ART initiation arm:initial ART =14 days after TE treatment
the deferred ART initiation arm:initial ART >14 days after TE treatment
Sponsors
Chongqing Public Health Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: (1) Adult (defined as >= 18 years of age); (2) Confirmed HIV infection; (3) Diagnosed with TE; (4) ART-native; (5) Willingness to give an informed consent.
Exclusion criteria
Exclusion criteria: (1) Allergic or intolerant to ART drugs; (2) Hemoglobin (Hb) 2 x UNL, serum creatinine (Scr) >1.5 x UNL, aspartate aminotransferase (AST) /alanine aminotransferase (ALT) /alkaline phosphatase (ALP) > 5 times of UNL, total bilirubin (TB) >2 x UNL, serum creatine phosphokinase (CK) > 2 x UNL; (3) Pregnancy or breast-feeding; (4) Severe cardiovascular disease, liver disease, kidney disease, lung disease or other diseases that may reduce patient compliance; (5) Severe mental illness; (6) Patients with intravenous recreational drug use; (7) Non-Chinese nationality.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the overall mortality at week 48; | — |
Secondary
| Measure | Time frame |
|---|---|
| CD4+ cell counts from baseline to week 48;the rate of virologic suppression at week 48;the incidence of TE-IRIS;the incidence of AEs; | — |
Countries
China
Contacts
Public ContactYaokai Chen
Chongqing Public Health Medical Center
Outcome results
None listed