bipolar disorder
Conditions
Interventions
Group 1:antidepressants combined with mood stabilizers
Group 2:mood stabilizers
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 62 Years
Inclusion criteria
Inclusion criteria: 1) Meet the diagnostic criteria of bipolar I or bipolar II depression in DSM-IV; 2) A major depressive episode occurred within 3 months before enrollment, and the most recent episode was a major depressive episode; 3) Meet clinical remission criteria, defined as HAMD-17 <= 7 points, YMRS <= 7 points, CGI-S <= 2 points for at least 2 weeks; 4) 18-65 years old; 5) Patients voluntarily participated in the study and signed the informed consent by him/herself.
Exclusion criteria
Exclusion criteria: 1) Have been diagnosed of schizophrenia, schizoaffective disorder or other mental disorders associated with diseases; 2) Comorbid personality disorder or mental retardation; 3) Have substance abuse or dependence within 1 year before enrollment; 4) Currently have a serious risk of suicide judged by investigators or HAMD-17 item 3 (suicide item) score >= 3 points; 5) Currently have severe physical illnesses which researchers think it is risky and not eligible to participate; 6) Pregnant or lactating women, or those who are planning to become pregnant, or who do not agree with contraception; 7) Have received electroconvulsive therapy within 1 month before enrollment; 8) Have participated in another interventional clinical study within 1 year before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to recurrence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of recurrence rate;Assessment of rehospitalization;Pharmacotherapy compliance;Hamilton Depression Rating Score;young manic rating scale;Clinical Global Impression;Globle assessment scale; | — |
Countries
China
Contacts
Public ContactWang Xue
Beijing Anding Hospital, Capital Medical University
Outcome results
None listed