multiple sclerosis
Conditions
Interventions
Healthy control group:N/A
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meets the 2010 McDonald MS diagnostic criteria; 2. Meet the "International Standard for Classification and Diagnosis of Diseases" (ICD-10 diagnostic criteria for mild and moderate depression (F32) depression, first diagnosis, first treatment; 3. HAMD-24 item scale score >= 20 points and < 35 points; 4. Age over 18 years and under 65 years; 5. MRI demyelination site in the skull; 6. Subjects volunteered and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Other treatments were performed before the start of this study; 2. Patients with acute MS who have a cortical state or coma; 3. Suffering from severe heart, liver and kidney dysfunction and other diseases that affect the stability of vital signs; 4. Patients during pregnancy or lactation; 5. People who have a significant tendency to commit suicide; 6. Serious adverse reactions in nuclear magnetic (MRS, DTI) scans that make the examination impossible; 7. In any other situation that the researcher considers unsuitable to participate in this trial, such as failure to cooperate with nuclear magnetic scanning as required by the research; 8. Patients with MS who have entered a relapse period during follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD-24;QIDS;The Kurtzke Expanded Disability Status Scale (EDSS);AIDS;5-HT;IL-1ß;TNF-a;IL-6;IL-2;IL-12;IL-4;IL-13;Fractional Anisotropy, FA;Apparent Diffusion Coefficient, ADC; | — |
Countries
China
Contacts
Public ContactXuesong Zhao
Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed