perioperative neurocognitive impairment
Conditions
Interventions
Sponsors
The First Affiliated Hospital, University of South China
Eligibility
Sex/Gender
All
Age
60 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1)aged >= 60 years; 2)scheduled to undergo elective hip and knee arthroplasty; 3)preoperative MMSE score >= 24; 4)informed consent to participate in the study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1) elders with severe visual, auditory, cognitive impairment, dementia or a history of mental illness; 2) elders with infection within one month; 3) elders with neurological diseases, such as ischemic or hemorrhagic stroke and severe head trauma; 4) elders with severe preoperative heart, liver and kidney disorders and malignant tumors; 5) those taking antidepressants or sedatives continuously before surgery; 6) those participating in other clinical trials within the past four weeks; 7) those unable to communicate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| trimethylamine N-oxide;postoperative delirium; | — |
Countries
China
Contacts
Public ContactWenjie Liu
The First Affiliated Hospital, University of South China
Outcome results
None listed