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Development and validation of diagnostic criteria for reversible posterior encephalopathy syndrome

Development and validation of diagnostic criteria for reversible posterior encephalopathy syndrome

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000031154
Enrollment
Unknown
Registered
2020-03-23
Start date
2020-04-01
Completion date
Unknown
Last updated
2020-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Posterior reversible encephalopathy syndrome

Interventions

Meets diagnostic criteria for reversible posterior encephalopathy syndrome:None
Not reversible posterior encephalopathy syndrome:None

Sponsors

The Affiliated Hospital of Guizhou Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Clinical manifestations of acute neurotoxicity with headache, altered mental state, seizures or altered vision, with or without elevated blood pressure; 2. Risk factors such as hypertension, eclampsia / preeclampsia, infection, autoimmune disease, use of immunosuppressive agents or cytotoxic drugs; 3. The reversible white matter edema of the posterior part of the bilateral cerebral hemisphere, especially the bilateral parietal occipital lobe, the lateral ventricle, the cerebellum, and the brainstem is shown on imaging to be equal or slightly lower on T1WI, and high on T2WI or FLAIR. DWI and ADC images show vasogenic edema; 4. After reasonable treatment, the clinical symptoms obviously improved or disappeared, and the lesions partially or completely disappeared on imaging.

Exclusion criteria

Exclusion criteria: 1. Patients with intracranial edema lesions secondary to ischemia, hemorrhage, infection, inflammation or mass occupying lesions were excluded; 2. exclude other possible white matter lesions; 3. Patients with or without diagnostic MRI were excluded.

Design outcomes

Primary

MeasureTime frame
Magnetic resonance examination;

Countries

China

Contacts

Public ContactBo Gao

Guizhou Medcial University

gygb2004@gmc.edu.cn+86 13964598087

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026