intrauterine adhension
Conditions
Interventions
Control Group:estrogen therapy
Sponsors
The Affiliated Yantai Yuhangding Hospital of Qingdao University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: (1) Women of childbearing aged 18 to 40 years old undergoing hysterscopic adhesiolysis; (2) Patients with moderate and severe uterine adhesion; (3) With regular menstruation and ovulation; (4) Agree to participate in the clinical study and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Previous surgery history for intrauterine adhesion; (2) Thrombosis, cardiovascular disease and respiratory disease or previous history; (3) Serious uterine malformation, endometrial tuberculosis or polyp, large intramural myoma, genital malformation and serious adenomyosis; (4) Acute reproductive tract infection; (5) Severe hepatorenal insufficiency: ALT>80U/L,Cr>100µmol/L; (6) There are history of thrombosis or high risk factors of thrombosis, such as antiphospholipid syndrome; (7) Patients with diseases that are not suitable to be treated with high dose estrogen; (8) Abnormal karyotype; (9) Abnormal thyroid or adrenal function; (10) History of pelvic tumor or other malignant tumor or received pelvic radiotherapy; (11) The use of drugs (such as hormones, prostaglandin inhibitors, psychotropic drugs) that may interfere with the evaluation of the study; (12) Patients with poor compliance such as inability or unwillingness to contact after discharge; (13) They had taken other experimental drugs or were participating in other clinical studies within one month before inclusion; (14) The doctor in charge thinks it is not suitable to participate in the clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| thickness of endometrium around ovulational peried;AFS;the clinical pregnancy rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| menstrual quantity;the pregnancy rate;abortion rate; | — |
Countries
China
Contacts
Public ContactHongchu Bao
The Affiliated Yantai Yuhangding Hospital of Qingdao University
Outcome results
None listed