type 2 diabetes
Conditions
Interventions
Group 2:metformin 2000mg/d
Group 1:Sitagliptin 100mg/d
Sponsors
the First Affiliated Hospital Division of Life Sciences and Medicine University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. T2D was diagnosed; 2. Aged 18 to 75 years old; 3. at least 10 weeks of stable metformin (1500mg / day) monotherapy was received before screening; 4. poor blood glucose control (HbA1c 7% to 10%); 5. Willing to participate in this study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Combined with endocrine and metabolic diseases affecting energy metabolism; 2. participate in weight loss programs, including drugs and surgery (within 12 months), or weight loss of more than 5% in the last three months; 3. surgery or planned surgery within 4 weeks; receive or need corticosteroid treatment or repeated treatment for more than 2 weeks; 4. serious digestive system diseases or digestive dysfunction; 5. serious liver diseases, such as cirrhosis (light to Moderate fatty liver can be selected); 6. obvious abnormality of liver and kidney function: serum creatinine level is more than 1.5 times of the upper limit value, or EGFR is less than 45ml / min / 1.73m2 calculated according to MDRD; 7. serum ALT and / or AST is more than 3 times of the upper limit value, or there are other obvious abnormal indexes; 8. accompanied with organ and system diseases, coronary heart disease, heart failure and related diseases; 9. mental disease; malignant tumor; participating in other intervention tests; 10. pregnant and lactating women; 11. using recreational or contraband drugs, or having a recent history of drug or alcohol abuse; 12. history of drug intolerance or allergy or contraindications; 13. history of medullary thyroid cancer.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HbA1c; | — |
Countries
China
Contacts
Public ContactZheng Xueying
the First Affiliated Hospital Division of Life Sciences and Medicine University of Science and Technology of China
Outcome results
None listed