Application of dexmedetomidine combined with ropivacaine in soft tissue infiltration to relieve pain after total knee replacement

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000031063

Enrollment

Unknown

Registered

2020-03-21

Start date

2020-04-01

Completion date

Unknown

Last updated

2020-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis

Interventions

experimental group:local infiltration analgesia with Dexmedetomidine and Ropivacaine

control group:local infiltration analgesia with Ropivacaine and saline

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: 1. Patients undergoing the primary total knee arthroplasty; 2. Patients with knee osteoarthritis; 3. ASA grades 1-3; 4. Aged < 85 years.

Exclusion criteria

Exclusion criteria: 1. Patients with bilateral TKA; 2. Patients were allergic to anesthetic drugs, NSAIDs or opioid drugs; 3. Opioid consumption on a daily basis; 4. With hepatic, renal or cardiac insufficiency; 5. BMI >= 35 Kg/m2; 6. With Coagulation disorders; 7. Patients with an inability to co-operate or to communicate.

Design outcomes

Primary

Measure	Time frame
total morphine consumption;	—

Secondary

Measure	Time frame
VAS score;First analgesic requirement;????;range of motion;range of motion;first time to walk;Thigh circumference;time to fulfilment of discharge criteria;length of stay;Side Effec;	—

Countries

China

Contacts

Public ContactShengwu Yang

The First Affiliated Hospital of Wenzhou Medical University

yangsw@foxmail.com+86 13806683212

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026