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The Role and molecular mechanism of nephrin endocytosis in podocyte injury of diabetic nephropathy by mediating energizing mode switching

energizing mode switching mediated by nephrin endocytosis and diabetic nephropathy

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000031062
Enrollment
Unknown
Registered
2020-03-22
Start date
2021-01-01
Completion date
Unknown
Last updated
2020-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetic nephropathy

Interventions

None listed

Sponsors

The First Affiliated Hospital of Shandong First Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with diabetic nephropathy whose pathological diagnosis is clear.

Exclusion criteria

Exclusion criteria: 1. With other secondary kidney diseases caused by autoimmune diseases, infections, tumors, drugs, poisons, etc; 2. Patients with primary glomerular disease; 3. Incomplete clinical and pathological data of diabetic nephropathy; 4. Patients unwilling to enroll.

Design outcomes

Primary

MeasureTime frame
Renal histopathology;nephrin expression in renal tissue;GLUT4 expression in renal tissue;LAT2 expression in renal tissue;4F2HC expression in renal tissue;kidney tissue metabolomics;—

Secondary

MeasureTime frame
blood sugar;Serum creatinine;Blood urea nitrogen;Blood insulin;Glycated hemoglobin;24-hour urine albumin quantification;—

Countries

China

Contacts

Public ContactYipeng Liu

Department of neprhroloy, The First Affiliated Hospital of Shandong First Medical University

liuyipeng@sdhospital.com.cn+86 13064089262

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026