Sensory disturbance after free skin flap
Conditions
Interventions
Nanofat combined with mouse nerve growth factor:Injection of nanometer fat and mouse nerve growth factor
Mouse nerve growth factor group:Injection of rat nerve growth factor
Nanometer fat group:Nanofat injection
Physiological saline group:Saline injection
Sponsors
Department of Burn Plastic Surgery, Affiliated Hospital of Zunyi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Those patients who underwent free anterolateral thigh perforator flap 4 months after operatio. 2. Patients with anastomotic nerve between flap and receiving area. 3. Patients with skin defect area of extremities: 90-150cm2. 4. Age 18 Mel 35 years old, BMI:18.5-23.9. 5. Patients without obvious cicatricial hyperplasia around the flap. 6. Informed that the operation is the first clinical application, there is an unpredictable risk, the skin, fat and related information of the operation will be applied to the study and published, and the patients and their families agree to the operation.
Exclusion criteria
Exclusion criteria: 1. Patients with pathological changes in important organs can not tolerate surgery. 2. A patient with a hematopoietic or immune system disease. 3. Patients with allergic constitution, scar constitution or abnormal physique. 4. Patients with mental illness. 5. Patients who are in the lactation period, menstruation period and pregnancy preparation period of a pregnant woman. 6. Patients with infected lesions in the recipient area. 7. Patients with peripheral neuropathy, vascular disease, diabetes, connective tissue disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Temperature sensation;Two-point discrimination;s-100;CD31;Optical density value;Neurotrophic factor; | — |
Countries
China
Contacts
Public ContactDeng Chengliang
Burn Plastic Surgery, Affiliated Hospital of Zunyi Medical University
Outcome results
None listed