Helicobacter pylori
Conditions
Interventions
Dual therapy group:High-dose amoxicillin combined with ezomeprazole
Control group:Bismuth Quadruple Therapy Group
Sponsors
The Affiliated Hospital of Southwest Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients, aged between 18-70 years. 2. Patients who did not take antibiotics, bismuth and traditional Chinese medicine 4 weeks before treatment, and patients who took PPI, H2 receptor antagonists and other drugs that affect HP activity 2 weeks before treatment; 3. Patients who were initially diagnosed as HP positive by C13 or C14 urea breath test, rapid urease test and histopathology, and who had not received HP eradication treatment before; 4. Informed and agreed to participate in the study, patients with complete medical records and follow-up records.
Exclusion criteria
Exclusion criteria: 1. With severe heart, lung, and kidney dysfunction and low immunity; 2. Patients with drug allergy contraindications; 3. Persons with mental illness or communication difficulties; 4. Pregnancy, lactation; 5. Patients with organic diseases such as gastrointestinal tumor and gastrointestinal hemorrhage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Compliance;Adverse reactions;Cost of treatment; | — |
Countries
China
Contacts
Public ContactChangping Li
The Affiliated Hospital of Southwest Medical University
Outcome results
None listed