Pneumoconiosis
Conditions
Interventions
high pressure group of negative suction:high pressure of negative suction
low pressure group of negative suction:low pressure of negative suction
experimental group:Injection of penehyclidine hydrochloride
Blank control group:Injection of physiological saline
Sponsors
Emergency General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Aged 18 -70 years; sex unlimited; (2) FEV1% limited; (3) PaO2 > 70mm Hg; (4) According to epidemiological and occupational history, the patients were diagnosed as pneumoconiosis by X-ray, and needed double lung lavage at the same time; (5) The subjects or their guardians can understand the purpose of this trial, show fully compliance and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients who underwent excessive lung lavage within one year; (2) Those with severe tracheobronchial malformations that prevented the double lumen trachea catheter from being in place; (3) Those with acute respiratory tract infection and had not been cured; (4) Those with active tuberculosis; (5) Those with bullae whose diameter of subpleura were more than 2cm; (6) Severe emphysema (residual volume / total lung volume >=46%); (7) Severe pulmonary dysfunction (MVV 1.5 times of normal upper limit); (9) Uncontrolled hypertension (systolic blood pressure > 140mmHg or diastolic blood pressure > 95mmHg); (10) Leukopenia (WBC < 4 x 10^9/L or neutrophils < 0.5 x 10^9/L).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vital signs;Blood gas analysis;Inflammatory cytokines; | — |
Countries
China
Contacts
Public ContactQinghao Cheng
Emergency General Hospital
Outcome results
None listed