Pulmonary nodule or tumor
Conditions
Interventions
Saline-propofol group:Normal saline
Dexmedetomidine-propofol group:Dexmedetomidine
Saline-sevoflurane control group:Normal saline
Dexmedetomidine-sevoflurane group:Dexmedetomidine
Sponsors
First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients who can sign informed consent; 2. 18-65 years old; 3. ASA class I-III; 4. Patients who scheduled to undergo thoracoscopic lobectomy.
Exclusion criteria
Exclusion criteria: 1. With any contraindications to regional techniques (allergy to local anesthetics, infection around the site of the block, and coagulation disorder); 2. With a history of analgesics dependence; 3. Any person with communication difficulties or dementia; 4. Patients allergic to the study drug; 5. Heat rate < 50 beats/minutes or II-III Atrioventricular block; 6. Those who were transferred to an open chest operation; 7. Who had an estimated intraoperative blood loss of more than 500 mL.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Remifentanil consumption;postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| opioid consumption;VAS score at rest;VAS scores at coughing;Times for press pump;Time to pass flatus;Major complications (including nausea, vomiting, incision infection, cardiovascular and cerebrovascular events, acute liver and kidney injury, etc.);Length of stay;mortality;Adrenaline, noradrenaline and cortisol; | — |
Countries
China
Contacts
Public ContactGuanghong Xu
First Affiliated Hospital of Anhui Medical University
Outcome results
None listed