Persistent allergic rhinitis
Conditions
Interventions
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with persistent AR according to Chinese Guideline of Allergic Rhinitis; 2. All the participants had positive response (++ or above) to at least one allergen in skin prick test (SPT) using standard reagents within 12 months(wheal diameter of positive control >=3mm and wheal diameter of allergen >=3mm; wheal diameter=(the longest diameter+its vertical diameter)/2; skin index(SI)= wheal diameter of allergen/wheal diameter of positive control; +: SI2.0); 3. The average VAS for rhinorrhea should be over 5.0 during screening period; 4. Patients could understand the protocol, cooperate and complete the whole trial; 5. Patients signed informed consents; 6. Patients did not participate any other clinical trial within 3 months.
Exclusion criteria
Exclusion criteria: 1. Patients with other nasal disease except for persistent AR, such as rhinosinusitis, nasal tumor and deviated nasal septum; 2. could not stop using antihistamines, vasoconstrictors, or glucocorticoids; 3. had experienced injuries or operations on nose or eyes in previous 3 months; 4. were allergic to anticholinergics; had a history of glaucoma, cataract, prostatitis, prostatic hypertrophy and urinary calculus; 5. in acute disease condition; had any systemic diseases; 6. pregnant or lactating; 7. Patients were also excluded if they had applied antihistamines, anti-leukotrienes, anticholinergics or Chinese herb medicine for AR within 7 days, and applied vasoconstrictors in 3 days, tricyclic antidepressant in 14 days and glucocorticoid in 30 days before screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual analog scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| anterior rhinoscope scoring; | — |
Countries
China
Contacts
Public ContactLiu Shixi
West China Hospital, Sichuan University
Outcome results
None listed