corneal blindness
Conditions
Interventions
Case series:Keratoprosthesis implantation
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: This clinical trial aims at patients with severe corneal blindness in both eyes, end-stage corneal blindness patients who cannot achieve long-term rehabilitation of corneal blindness through any other corneal transplantation surgery, including the cases with severe corneal vascularization, end-stage dry eyes, severe eyelid conjunctival sac abnormality or eyelid atresia, multiple corneal transplantation failures, etc., and cases who give up corneal transplantation after they have been confirmed by corneal experts in other medical institutions. At the same time, the following basic conditions should be met: 1. 18 years of age or older; 2. Retina and optic nerve structure and function with visual potential rehabilitation; 3. The primary diseases and inflammation of the eyes are basically stable, and there is no active infection (especially chemical, thermal burns and autoimmune diseases) ); 4. Normal IOP measurement by hands or IOP basically under control without medication in cases with glaucoma; 5. Make regular follow-up visits successfully as required; 6. Understanding related conditions of keratoprosthesis including indications and surgical risks; 7. Ability to follow postoperative requirements and instructions strictly (medication, follow-up, etc.).
Exclusion criteria
Exclusion criteria: 1. who have severe systemic diseases and couldn't tolerate surgery; 2. those who can restore eyesight by corneal transplantation; 3. those whose IOP couldn't be under control or be stable without medication; 4. the original disease is unstable such as chemical burns, thermal burns and other inflammations; 5. poor function of the retina or optic nerve (no potential to restore vision); 6. those who do not understand the risk of keratoprosthesis surgery, can not regularly follow up and take the medication as required.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the rate of relief from blindness; | — |
Secondary
| Measure | Time frame |
|---|---|
| the rate of keratoprosthesis in eye;best corrected visual acuity; | — |
Countries
China
Contacts
Public ContactYifei Huang
First Medical Center, PLA General Hospital
Outcome results
None listed