Heart Transplantation
Conditions
Interventions
Intensive sampling arm:Ten peripheral venous blood were collected before taking MPA at steady state and 0.5 ~ 12 h after taking the medicine, and the gene polymorphism was detected.
Sparse sampling arm:Collect 5 to 6 MPA plasma concentrations each time
The above blood collection points may be adjusted according&
Validation arm:Fifteen patients for external validation were enrolled. MPA samples were collected according to the optimally designed with the minimum number of samples, and individual PK parameters w
Sponsors
Guangdong General Hospital (Guandong Academy of Medical Sciences)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Heart transplant recipients who is taking mycophenolate mofetil; 2. Co-medication wtih tacrolimus or cyclosporin; 3. Male of female, aged 18-75 years; 4. Multiple sample collection is acceptable for the patients; 5. Good treartment compliance and integrate medical records.
Exclusion criteria
Exclusion criteria: 1. Mycophenolate mofetil immediate release tablets are changed to the enteric coated formulations for severe gastrointestinal reactions; 2. Patients who are allergic to mycophenolate mofetil or mycophenolic acid (MPA); 3. Bad treatment compliance; 4. The research physician did not consider it appropriate for the enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentration of mycophenolic acid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Genotypes; | — |
Countries
China
Contacts
Public ContactMin Wu
Guangdong Cardiovascluar Institute
Outcome results
None listed