Comparison of Picosecond 1,064nm Laser and Q Switch Nd: YAG 1,064nm Nanosecond Laser in the Treatment of Melasma: a Prospective, Randomized, Split-face, Clinical Trial

Comparison of Picosecond Nd: YAG 1,064nm Laser and Nanosecond Q-Switched Nd: YAG 1,064nm Laser in the Treatment of Melasma: a Prospective, Split-face, Randomized, Clinical Trial

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000030886

Enrollment

Unknown

Registered

2020-03-16

Start date

2020-03-20

Completion date

Unknown

Last updated

2020-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Melasma

Interventions

control group:Picosecond laser

experimental group:Q Switch Nd: YAG Laser

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Adults between the ages of 18 and 50 years; 2. Patients who are diagnosed as chloasma; 3. Patients who voluntarily participated in the study and signed the informed consent.

Exclusion criteria

Exclusion criteria: 1. Women in pregnancy or lactation; 2. Patients with a history of Photosensitivity; 3. With histories of any light, laser or ultrasound therapy in 1 year; 4. With histories of any treatments of melasma (including: tranexamic acid, isotretinoin, topical use of steroid or hydroquinone and etc.) in 1 year.

Design outcomes

Primary

Measure	Time frame
the modified melasma area and severity index (mMASI);	—

Secondary

Measure	Time frame
satisfaction questionnaire;VAS;	—

Countries

China

Contacts

Public ContactHuang Lvping

Plastic Surgery Hospital of Chinese Academy of Medical Sciences

414700347@qq.com+86 10-85557900

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 25, 2026