A modified procedure of in vitro activation of follicles for infertility treatment of patients with premature ovarian insufficiency

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000030872

Enrollment

Unknown

Registered

2020-03-16

Start date

2016-03-01

Completion date

Unknown

Last updated

2020-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

premature ovarian insufficiency

Interventions

Case series:In vitro activation of primordial follicles following with autologous transplantation

Eligibility

Sex/Gender

Female

Age

25 Years to 43 Years

Inclusion criteria

Inclusion criteria: Premature ovarian insufficiency (POI) patients were selected based on a history of amenorrhea for >1 y before 40 y of age and serum FSH levels >40 mIU/mL; POR (poor ovarian response) patients with DOR (decreased ovarian reserve) were recruited based on the Bologna criteria. The minimal criteria needed to define POR when at least two of the following three fea-tures must be present: 1. advanced maternal age or any other riskfactor for POR; 2. a previous POR; 3. an abnormal ovarianreserve test (ORT).

Exclusion criteria

Exclusion criteria: Patients with chromosomal abnormality, endometrosis, thyroid gland dysfunction, previous ovarian surgery, and pelvic radio/chemotherapy were excluded. Patients whose husband are with chromosomal or sperm abnormality was also excluded.

Design outcomes

Primary

Measure	Time frame
Follicular development;FSH;estrogen;AMH;	—

Countries

China

Contacts

Public ContactLi Jing

Nanjing Medical University

ljwth@njmu.edu.cn+86 25 86869503

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 15, 2026