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The efficacy of modified minimally invasive technique (M-MIST) combined with Bio-oss Collagen in the regenerated treatment of periodontitis with introbony defect: a randomized, single-blind, controlled clinical study

The efficacy of modified minimally invasive technique (M-MIST) combined with Bio-oss Collagen in the regenerated treatment of periodontitis with introbony defect: a randomized, single-blind, controlled clinical study

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000030851
Enrollment
Unknown
Registered
2020-03-15
Start date
2020-03-31
Completion date
Unknown
Last updated
2020-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Interventions

control group:modified minimally invasive technique
experiment group:modified minimally invasive surgical technique combined with bio-oss Collagen

Sponsors

Department of Periodontology, Stomatological Hospital of Beijing University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Patients criteria (1) Above the age of 18 years; (2) Patients with periodontitis 1-2 months after periodontal basic treatment; (3) Patients with good compliance; (4) Patients with good oral hygiene, the full mouth plaque score is less than 30%; full mouth bleeding score less than 30%; 2. Morphological requirements of the subosseous pocket (explore during the operation, and finally determine whether to be enrolled) (1) At least one tooth had a depth of PD and attachment loss of AL more than 5mm on the adjacent surface, and the depth of the subosseous pocket was at least 3mm; (2) Subosseous bag involving but not exceeding 1/3 of the root surface. 3.Dental standards (1) Normal pulp vitality or complete complete root canal treatment (6 months); (2) The anterior teeth, the premolars, and the mesial side of mandibular first molars.

Exclusion criteria

Exclusion criteria: 1. Combined with tumor; 2. There is serious uncontrolled systemic disease (e.g., high blood pressure, diabetes, heart disease); 3. Patients who have received antibiotics, non-steroidal anti-inflammatory drugs or periodontal therapy in the past 3 months; 4. Patients who smoke or smoke more than 10 cigarettes / day; 5. Pregnant and lactating women; 6. With the affected teeth with 3-degree mobility, furcation involvement, acute perioapical inflammation and root fractures.

Design outcomes

Primary

MeasureTime frame
Clinical Attachment Loss;bone fill;Probing Depth;postoperative pain;—

Secondary

MeasureTime frame
Full Mouth Plaque Scores;Full Mouth Bleeding Scores;Gingival Recession;Height of the gingival papillar;—

Countries

China

Contacts

Public ContactKaining Liu

Department of Periodontal, Stomatological Hospital of Beijing University

liukainingbjmu@163.com+86 13466502549

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026