Cognitive dysfunction in gynecological patients
Conditions
Interventions
Saline group:5ml of 0.9% physiological saline solution was injected. Esketamine was not added to the postoperative analgesic pump, and an equal amount of normal saline was used instead. No difference
Analgesic pump administration group:Add 40mg esketamine to analgesia pump after anesthesia
Single intravenous combined analgesia pump:During anesthesia, esketamine was injected intravenously at 0.25 mg / kg, and dissolved in 5 ml of a colorless transparent solution using 0.9% physiological
Sponsors
Department of Anesthesiology, Shengjing Hospital, China Medical University
Eligibility
Sex/Gender
Female
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients aged over 40 years who were selected for gynecological surgery at Shengjing Hospital were selected. The inclusion criteria were: patients who underwent laparotomy in Shengjing Hospital: 1. Patients aged >= 40 years; 2. Surgery time >= 2h; 3. Good coordination, able to understand and cooperate with the completed measurement scale; 4. ASA classification Grade I-III.
Exclusion criteria
Exclusion criteria: 1. Patients with mental illness such as depression; 2. Refusal to use postoperative analgesia pumps; 3. Patients with severe obstetric complications or severe underlying diseases such as hypertension, hyperthyroidism, epilepsy, increased intracranial pressure or cranial Ketamine contraindications such as internal space-occupying lesions and a history of cardiovascular and cerebrovascular accidents; 4. History of drug and alcohol addiction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini mental status examination (MMSE) assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| preoperative data;intraoperative data;Postoperative indicators; | — |
Countries
China
Contacts
Public ContactPing Zhao
Department of Anesthesiology, Shengjing Hospital, China Medical University
Outcome results
None listed