coronary artery stenosis
Conditions
Interventions
Experimental group D1:DEX 0.1µg/kg/h introvenous infusion
Experimental group D3:DEX 0.3µg/kg/h introvenous infusion
Experimental group D5:DEX 0.5µg/kg/h introvenous infusion
Control group C:0.9%NS introvenous infusion
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: This study was approved by the Research Ethics Committee of the Second Hospital of Shandong University ,all patients or authorized family members have signed informed consent. Two to four coronary artery disease or left main coronary artery disease; ASA II-IV.
Exclusion criteria
Exclusion criteria: Left ventricular aneurysm; Acute myocardial infarction within two weeks; Acute heart failure; Severe heart valve disease; Severe systemic diseases (such as significant abnormal liver and kidney function); Preoperative diagnosis of bradycardia or heart rate < 50 bpm;Left bundle branch block, degree II or degree III atrioventricular block; Previous history of drug dependence or mental illness; Allergic to dexmedetomidine and its ingredients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cardiac troponin I;major cardiovascular adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| intraoperative sulfentanil consumption;minimun alveolar concentration of sevoflurane;vasoactive drug consumption;postoperative extubation time;ICU staying time;hemodynamic parameter;length of hospitalization;hospitalization expenses;Lidocaine dosage; | — |
Countries
China
Contacts
Public ContactYanwu Jin
The Second Hospital of Shandong University
Outcome results
None listed