Effects of aural vagus nerve stimulation on brain injury markers in patients with severe craniocerebral trauma

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000030785

Enrollment

Unknown

Registered

2020-03-14

Start date

2019-02-01

Completion date

Unknown

Last updated

2020-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe craniocerebral trauma

Interventions

Control group and aural vagus nerve stimulation group:Aural vagus nerve stimulation

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Severe craniocerebral trauma patients admitted to our hospital from February 2019 to March 2020, age 18-60 years old, gender no restriction, can be combined with other injuries; The injury time ranged from 1 to 10 days, and the GCS scores were all 8 points. The patient's family members were informed voluntarily and signed the informed consen.

Exclusion criteria

Exclusion criteria: Intracranial pressure > 30 MMHG. Active intracranial bleeding; Previous history of cerebral trauma after encephalitis stroke; Complicated with diseases of heart, liver, lung, kidney and blood; Implantation of various kinds of pacemakers and patients with frequent cardiac arrhythmia; Pregnant women; Patients with hydrocephalus or intracranial pressure increase of 30mmHg; Previous vagotomy; Chronic hypoxia with hypotension.

Design outcomes

Primary

Measure	Time frame
GCS;DRS;EEG;TNF-alph;IL-1;IL-6;IL-10;GFAP;Ubiquitin carbon terminal hydrolytic enzyme;	—

Countries

China

Contacts

Public ContactXueqing Li

The Second Hospital of Hebei Medical University

Lixueqingsophia@sina.com+86 18233120987

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026