Juvenile Dermatomyositis
Conditions
Interventions
MSA positive group vs. MSA negative group :N/A
Sponsors
The Affiliated Children's Hospital, Capital Institute of Pediatrics
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged < 18 years; 2. Diagnosed juvenile dermatomyositis, including dermatomyositis, polymyositis and clinical amyopathic dermatomyositis; 3. Parents/guardians agree that children should participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Merging other diseases that may cause muscle lesions and muscle weakness; 2. Immune abnormality caused by primary immunodeficiency or allergic constitution; 3. The patient is within the process of acute or chronic infection, or has a past history of active tuberculosis; HbsAg(+) or anti-HCV(+); 4. The patient has psychiisatric disorders or other reasons that can not cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myositis antibody spectrum (including but not limited to anti-Jo-1, PL-7, PL-12, EJ, SRP, Mi2, MDA5, TIF1?, HMGCR, SSA/Ro52kD, SAE1/2, NXP2 antibodies);Childhood Myositis Assessment Scale;Cutaneous Assessment Tool for Myositis-Binary Method;Serum enzyme level (including CK, CKMB, LDH, HBDH, ALT, AST);other organs besides muscle; | — |
Secondary
| Measure | Time frame |
|---|---|
| Routine blood tests;urine routine examination;Stool routine examination;Liver function;renal function;Lipids;blood glucose;Serum electrolytes;Serum calcium;Serum phosphorus;ESR;CRP;SF;KL-6;ANA;cellular immunity;humoral immunity;cytokines;muscle MRI;electromyography;muscle tissue biopsy;pulmonary high-resolution CT;abdominal ultrasound;electrocardiogram; | — |
Countries
China
Contacts
Public ContactJianguo Li
The Affiliated Children's Hospital, Capital Institute of Pediatrics
Outcome results
None listed