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The relationship between Helicobacter pylori infection and symptomatic intracranial atherosclerotic stenosis

The relationship between Helicobacter pylori infection and symptomatic intracranial atherosclerotic stenosis

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000030737
Enrollment
Unknown
Registered
2020-03-12
Start date
2020-03-20
Completion date
Unknown
Last updated
2020-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

case series:N/A

Sponsors

Guangdong Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients who meet the diagnostic criteria; 2. Patients above the age of 18 years; 3. Patients within 3 months; 4. Patients with at least one risk factor for atherosclerosis, such as hypertension, diabetes, hyperlipidemia, smoking, and alcohol consumption; 5. Patients with responsible intracranial artery stenosis confirmed by DSA; Or the patients confirmed by brain MRA, CTA and TCD to have responsible intracranial artery stenosis and to be examined by DSA; 6. Patients who can sign informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients whose clinical symptoms are caused by a series of extracranial artery stenosis; 2. Score of MRS > 1 before the stroke; 3. Patients with intracranial vascular occlusion; 4. Patients with intracranial artery stenosis related to vascular malformation, moyamoya disease or arteritis, aneurysm, etc.; 5. Patients with cerebral hemorrhage or subarachnoid hemorrhage or traumatic cerebral infarction confirmed by skull impact examination; 6. Patients with cerebral infarction due to cardiogenic stroke and other possible causes such as vasculitis, coagulation abnormality and tumor embolism; 7. Patients taking proton pump inhibitors, antibiotics, bismuth and other drugs that affect HP detection within 2 weeks before admission; 8. With treatment history of helicobacter pylori; 9. Patients with obvious infection of respiratory system and urinary system on admission.

Design outcomes

Primary

MeasureTime frame
helicobacter pylori;

Secondary

MeasureTime frame
TH1/TH2 related cytokines;hs-CRP;blood biochemical index;Cerebrovascular imaging;

Countries

China

Contacts

Public ContactHu Mingzhe

Guangzhou University of Chinese Medicine

mingzhe0818@126.com+86 13265337871

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026