Weaning of mechanical ventilation
Conditions
Interventions
Tracheostomy mask group: Patients randomized to tracheostomy mask were disconnected from the ventilator and were allowed to breathe through the tracheostomy via tracheostomy mask
Cannula oxygen group:Patients randomized to tracheostomy mask were disconnected from the ventilator and were provided with cannula oxygen through the tracheostomy
Sponsors
Critical Care department of Shenzhen Hospital, Southern Medical University
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Consecutive tracheotomized patients aged > 18 years, in ICU settings were screened. Patients will be eligible if they admit to acute respiratory failure and they have not successfully weaned within 24 hours of this first separation attempt after tracheostomy. Within 24 hours of tracheostomy, a separation attempt will be performed when the assessment for weaning is positive. The readiness of weaning is determined by the criteria used in previous studies: (1) reversal of the acute phase of the disease; (2) adequate oxygenation (PaO2 arterial oxygen-PaO2/FiO2 of 150-200 necessitating positive end-expiratory pressure (PEEP) = 8 g/dl).
Exclusion criteria
Exclusion criteria: Patients meet the following criteria excluded for this study: antecedent neuromuscular disease, hemodynamic instability (decompensated heart insufficiency, arrhythmia, acute coronary insufficiency), hemoptysis, spinal cord injury above T8, deep nerve defects, bilateral phrenic nerve injury, need of any type of home mechanical ventilatory support prior to hospitalization, any skeletal pathology that weakens chest wall movements such as severe kyphoscoliosis, congenital anomaly or contractures, poor general prognosis with less than 1 year life expectance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the proportion of successful weaning patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| the patient conditions after 28 days without invasive ventilation;ICU length of stay;hospital length of stay;related adverse events; | — |
Countries
China
Contacts
Public ContactYong Liu
Shenzhen Hospital, Southern Medical University
Outcome results
None listed