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The predictive value of small-airway function parameters and fractional exhaled nitric oxide for bronchial hyperresponsiveness in typical asthma patients with FEV1 = 80%predicted

Study of the predictive value of small-airway function parameters and fractional exhaled nitric oxide for bronchial hyperresponsiveness in asthma patients with FEV1 = 80%predicted

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000030725
Enrollment
Unknown
Registered
2020-03-12
Start date
2020-04-01
Completion date
Unknown
Last updated
2020-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

asthma

Interventions

Gold Standard:Recurrent syndromes of dyspnea, cough, wheeze, and chest tightness combined with positive bronchoprovocation test.
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Sponsors

Shanghai General Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Aged 18-75 years, recurrent symptoms of chronic dyspnea, dry cough, wheeze, or chest tightness at least eight weeks duration, predicted FEV1 of 80% or greater with spirometric measurement, normal HRCT results.

Exclusion criteria

Exclusion criteria: Had respiratory tract infections in the past 8 weeks, peripheral blood test indicates abnormal but eosinophils, using montelukast, long-acting ß2-agonists, theophylline, anticholinergic agents, inhaled or oral corticosteroid in the previous 4 weeks, or having concomitant severe systemic diseases. Patients with current smoking history or a history of cessation less than 2 years.

Design outcomes

Primary

MeasureTime frame
Spirometry;FENO;IOS;Bronchial provocation test;SEN, SPE, ACC, AUC of ROC;

Countries

China

Contacts

Public ContactWuping Bao

Shanghai General Hospital

wupingbao1982@163.com+86 13641688269

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026