Novel Coronavirus Pneumonia (COVID-19)
Conditions
Interventions
experimental group:Ixekizumab and antiviral therapy
control group:antiviral therapy
Sponsors
Xiangya Hospital of Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years old; 2. The diagnosis of new-type coronavirus pneumonia was confirmed by RT-PCR or gene sequencing according to the "Diagnosis and Treatment Scheme for Pneumonia of New Coronavirus Infection (Trial Version 6 and Updated)", and the clinical type was general (including severe high-risk factors) and severe; Note: Patients with common new type of coronavirus pneumonia (including severe high-risk factors): patients with common type with multiple lung multiple lesions, or pulmonary imaging shows that the lesion progresses significantly within 50% within 24 to 48 hours; 3. IL-6 is elevated (Roche chemiluminescence detection is recommended); 4. The patient voluntarily signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Critical new pneumonia infection that meets one of the following conditions: respiratory failure occurs and requires mechanical ventilation; shock; combined organ failure requires ICU monitoring and treatment 2. Known allergies to Ixekizumab or antiviral drugs; 3. ALT / AST> 5 times ULN, neutrophils =2 mg/dl (176 umol/l); 5. Combined with severe underlying diseases, the expected life cycle is less than 3 months; 6. Active hepatitis, patients with definite severe bacterial and fungal infections, tuberculosis infection, and HIV infection; 7. Clear diagnosis of malignant tumors such as lymphoproliferative diseases; 8. Known active Crohn's disease; 9. Pregnant or lactating women; 10. Participated in other interventional clinical trials in the past 3 months; 11. Other conditions that the researcher considers unsuitable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lung CT; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lung function;Arterial blood gas analysis ; | — |
Countries
China
Contacts
Public ContactPinhua Pan, Yehong Kuang
Xiangya Hospital of Central South University
Outcome results
None listed