Endometriosis
Conditions
Interventions
control group:Nil
experimental group 1:Estradiol 1mg+ progesterone 5mg
experimental group 2:Estradiol 0.5mg+ progesterone 5mg
Sponsors
Obstetrics and Gynecology Hospital Affiliated to Medical College of Zhejiang University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Patients with moderate or severe endometriosis through laparoscopy or laparotomy conservative treatment, pathologically confirmed endometriosis; 2. Stages III-IV of the Endometriosis Staging (AFS) criteria revised by the American Fertility Association; 3. Who has been approved by the Ethics Committee of Zhejiang University School of Medicine, agreed to use the research drug treatment, and signed relevant informed consent; 4. Aged 20 to 45 years.
Exclusion criteria
Exclusion criteria: 1. With histories of hypertension, diabetes, and cancer; 2. Patients with abnormal liver function and renal function; 3. Patients with poor compliance 4. Patients with a recent history of taking hormone drugs; 5. Those who have been treated with hormonal drugs 3 months before the start of the study, who are in lactation or pregnancy or are unable to undergo hormonal treatment with severe diseases; 6. Patients who have used other drugs, hormones and drugs affecting bone mineral density for EMS 3 months before treatment; 7. People with osteoporosis or other comorbidities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Kupperman score;Estrogen;FSH;BMD(bone mineral density); | — |
Secondary
| Measure | Time frame |
|---|---|
| EHP-5 score;hepatic function; | — |
Countries
China
Contacts
Public ContactLiqing Chen
Obstetrics and Gynecology Hospital Affiliated to Medical College of Zhejiang University
Outcome results
None listed