bipolar disorder
Conditions
Interventions
Group A1:S1 was used as the stimulus site, and 10 true stimuli were followed by 10 false stimuli
Group A2:S1 was used as the stimulus site, and 10 false stimuli were followed by 10 true stimuli
Group B1:S2 was used as the stimulus site, and 10 true stimuli were followed by 10 false stimuli
Group B2:S2 was used as the stimulus site, and 10 false stimuli were followed by 10 true stimuli
Sponsors
The First Affiliated Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 16 to 65 years; 2. Informed is signed by a subject or his lineal relation; 3. Comply with the DSM-IV clinical diagnostic criteria for bipolar depressive disorder; 4. Score of Beck-Rafaelsen Mania Rating Scale = 17 points; 7. The duration of the euthymic period >= 3 months; 8. Right-handed, has completed more than 9 years of compulsory education; 9. Score of the simple wechsler intelligence test > 80 points.
Exclusion criteria
Exclusion criteria: 1. A history of loss of consciousness due to organic brain disease or head trauma; 2. History of any major or unstable cardiovascular, respiratory, nervous system (including epilepsy or significant cerebrovascular disease), kidney, liver, endocrine or immune diseases; 3. Laboratory indicators or ECG abnormalities of clinical significance; 4. Magnetic resonance imaging revealed structural abnormalities in the brain; 5. Have hearing problems; 6. Red, green, blue or yellow color blindness or color weakness; 7. Patients who received ECT or rTMS within six months; 8. Patients with significant mental retardation and history of seizures; 9. History of psychoactive substance abuse and dependence; 10. There are pacemakers, insulin pumps, artificial heart valves and other things that have metal in them; 11. History of using anticholinergic drugs; 12. A pregnant, nursing or planning pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| THINC-it neurocognitive function assessment;Cranial magnetic resonance; | — |
Secondary
| Measure | Time frame |
|---|---|
| 17 items of Hamilton depression scale;Bech-Rafaelsdn Mania Rating Scale; | — |
Countries
China
Contacts
Public ContactShaohua Hu
The First Affiliated Hospital, Zhejiang University School of Medicine
Outcome results
None listed