Postoperative analgesia
Conditions
Interventions
Intrathecal hydromorphone group:Intrathecal 100µg hydromorphone and 2.5mg ropivacaine
Control group:Multimodal analgesia
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
21 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1) Adult patients (age range 18 to 65 years); 2) Scheduled to undergo elective partial hepatectomy with general anesthesia; 3) American Society of Anesthesiologists (ASA) classification I to III.
Exclusion criteria
Exclusion criteria: 1) Refuse to participate in the study; 2) Obese patients; 3) Any contraindication to spinal anesthesia, including coagulation dysfunction (platelets 1.5, or using anticoagulants therapeutically), or abnormal vertebral anatomy, or previous spinal trauma or surgery,or puncture site infection,or severe chronic back pain; 4) Suspected spinal metastases of malignant tumor; 5) Chronic pain syndrome or current opioid use of more than 60 oral morphine mg equivalents per day; 6) Allergic to drugs relevant to the study; 7) Poor comprehension of the research process and assessment; 8) Refusal to use the patient-controlled intravenous analgesia (PCIA) pump; 9) Participated in other clinical trials within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of moderate to severe pain with movement at 24 h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of moderate to severe pain with movement (30 min, 48 h, 72 h);the incidence of moderate to severe pain at rest (30 min, 24 h, 48 h, 72 h);The pain scores at rest and with movement within 72 h;Total hydromorphone uses at 24 h after surgery;Total hydromorphone uses at 72 h after surgery;The proportion of requiring additional analgesic within 72 h;The time to the first require additional analgesic;The proportion of requiring additional analgesic from 24h to 72 h;the proportion of getting out of bed within 24h;Overall satisfaction with analgesia;Exhaust time;Urinary catheter retention time;15-item quality of recovery scale;Length of stay in hospital after surgery; | — |
Countries
China
Contacts
Public ContactQian Li
West China Hospital, Sichuan University
Outcome results
None listed