Gynecological diseases
Conditions
Interventions
control group:5ml of 0.9% physiological saline solution was injected. Esketamine was not added to the postoperative analgesic pump, and an equal amount of normal saline was used instead. No difference
Analgesic pump set:Add 40mg esketamine to analgesia pump after anesthesia
Ketamine combined analgesia pump:During anesthesia, esketamine was injected intravenously at 0.25 mg / kg, and dissolved in 5 ml of a colorless transparent solution using 0.9% physiological saline. Ad
Sponsors
Shengjing Hospital affiliated to China Medical University
Eligibility
Sex/Gender
Female
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Women aged 30-60 who can understand and independently complete the questionnaire and choose to undergo gynecological operation without menopause; 2. American Association of Anesthesiologists I-II; 3. Patients who can understand and complete the questionnaire independently.
Exclusion criteria
Exclusion criteria: 1. With gynecological malignant tumor surgery; 2. Have a history of major depression and mental illness; 3. With previous ketamine contraindications such as severe refractory hypertension, pulmonary heart disease, hyperthyroidism, epilepsy, increased intracranial pressure or intracranial space-occupying lesions, and history of cerebrovascular accidents; 4. With a history of drug and alcohol addiction; 5. Patients who refuse to be included in clinical observation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| depression, anxiety; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative indicators: Adverse effects such as duration of operation, blood loss, medication, blood transfusion, and hypoxemia were recorded during the operation. Nausea, vomiting, nightmares, hallucinations, dizziness, and dizziness were recorded after entering the wake room and within 24 hours after surgery Adverse reactions;Postoperative indicators: Patients were evaluated for sleep quality, mini mental status examination assessment, and visual pain scale assessment; | — |
Countries
China
Contacts
Public ContactPing Zhao
Shengjing Hospital affiliated to China Medical University
Outcome results
None listed